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Ossip Groth (talk | contribs) (Created page with "sim. of crystalglobin-associated nephropathy: monoclonal protein–related crystalline nephropathies, light chain proximal tubulopathy, crystalline light chain cast nephropathy, crystal-storing histiocytosis, cryocrystalglobulinemia. table of all Monoclonal Protein–Related Renal Lesions given. mech: crystallization in endoplasmic reticulum, lysosomes (re-uptake), the in capillary lumina as TMA-lookalikes or small-vessel vasculitis. lm: nospecific, subsensitive ihc, eo...") |
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Revision as of 21:37, 31 January 2024
sim. of crystalglobin-associated nephropathy: monoclonal protein–related crystalline nephropathies, light chain proximal tubulopathy, crystalline light chain cast nephropathy, crystal-storing histiocytosis, cryocrystalglobulinemia. table of all Monoclonal Protein–Related Renal Lesions given.
mech: crystallization in endoplasmic reticulum, lysosomes (re-uptake), the in capillary lumina as TMA-lookalikes or small-vessel vasculitis. lm: nospecific, subsensitive ihc, eosinophilic material, pronase-digest stains Ig.
lab: myeloma workup, free light chains, marrow biopsy, albumin-autoantibodies, cryoglobulins.
treat: independent of myeloma activity chemo, cases bone marrow transplant. heroic plasmapherisis.
case: rpgn as tma-like lesion, corneal(eye) deposits (img shown)