Proliferative glomerulopathy with monoclonal deposits (MGRS)

• see also IL6_in_Liver_cirrhosis
• see also MPGN pattern with FSGS

26916379 PDF 2016. AJKD Atlas of Renal Pathology: Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits.

• mesangiocapillary==membranoproliferative
• structure-less deposits subendothelial, mesangial
• IgG3kappa mostly (big, anionic, complement fixing)
• polyclonal means k and l light chains i.e. at least 2 clones
• monoclonal oversimplifies only one type of light chain

36540764 PDF 2022. A Review on the Diagnosis and Treatment of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits.

• Monoclonal immunoglobulin diseases include light-chain deposition disease, light- and heavy-chain deposition disease,heavy-chain deposition disease, type I cryoglobulinemia, immune tubular glomerulopathy and fibrillar glomerulopathy. In recent years, the spectrum of monoclonal gammopathy has gradually expanded to include tissue deposits of monoisotype Ig but lacks evidence for a circulating monoclonal Ig component.
• fibrillary glomerulopathy, cryoglobulinemia type 1, membranous glomerulonephritis with IgGκ deposition, light-chain amyloidosis, light- and heavy-chain deposition disease, lupus nephritis, atypical anti-GBM nephritis with IgG deposition and idiopathic MPGN.
• daratumumab ==anti cd38
• 0.8% of kidney biopsies
• 20% terminal ki; 90% graft recurrence w early graft loss.
• nephritic/nphrotic init.
• no cryoglobulins (dd: cryo-crystalglobulinemic disease)

35664272 PDF 2022. An update of proliferative glomerulonephritis with monoclonal immunoglobulin deposits.'

30918151 PDF 2019. Monoclonal Immunoglobulin Deposition Disease and Related Diseases.Template:30918151
30665574 PDF 2019. Proliferative glomerulonephritis with monoclonal Ig deposits (PGNMID): diagnostic and treatment challenges for the nephrologist!Template:30665574
29996809 PDF 2018. Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts.Template:29996809
29759418 PDF 2018. A clone-directed approach may improve diagnosis and treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits.Template:29759418
26664209 PDF 2015. Proliferative glomerulonephritis with monoclonal immunoglobulin deposition disease: The utility of routine staining with immunoglobulin light chains.Template:26664209
26613031 PDF 2015. Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts.Template:26613031
26060375 PDF 2015. Glomerulonephritis with monoclonal IgG deposits.Template:26060375
23207123 PDF 2012. Proliferative glomerulonephritis with monoclonal immunoglobulin light chain deposits: a rare entity mimicking immune-complex glomerulonephritis.Template:23207123
19470674 PDF 2009. Proliferative glomerulonephritis with monoclonal IgG deposits.Template:19470674
14675039 PDF 2004. Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis.Template:14675039
35867238 PDF 2023. Poor outcomes of proliferative glomerulonephritis with monoclonal IgG deposits in renal allografts: a retrospective multicenter study.Template:35867238
35818814 PDF 2022. Long-term prognosis of monoclonal immunoglobulin-associated glomerular diseases with non-organized deposits: A report of 38 cases from a Japanese single center.Template:35818814

35460458 PDF 2022. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: an entity associated with distinct diseases and comparison between IgG1 and IgG3 subtypes.'

33494099 PDF 2021. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.Template:33494099
33044675 PDF 2021. Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients.Template:33044675
32001067 PDF 2020. Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits is associated with a high detection rate of the pathogenic plasma cell clone.Template:32001067
31825549 PDF 2020. Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance-related lesions in Latin America.Template:31825549
25939936 PDF 2015. Hematologic characteristics of proliferative glomerulonephritides with nonorganized monoclonal immunoglobulin depositsTemplate:25939936
30143498 PDF 2018. A Case of Switch from C3 Glomerulonephritis to Proliferative Glomerulonephritis with Monoclonal IgG Deposits.Template:30143498
29968411 PDF 2018. A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation.Template:29968411
29616329 PDF 2018. Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults.Template:29616329
25939936 PDF 2015. Hematologic characteristics of proliferative glomerulonephritides with nonorganized monoclonal immunoglobulin deposits.Template:25939936
3918930 PDF 1985. Single light chain subclass (kappa chain) immunoglobulin deposition in glomerulonephritisTemplate:3918930
25410550 PDF 2015. A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain.Template:25410550
25308093 PDF 2014. Proliferative glomerulonephritis due to monoclonal deposition with organized substructures.Template:25308093
24182705 PDF 2013. Monoclonal gammopathy-associated proliferative glomerulonephritis.Template:24182705
21705124 PDF 2011. Proliferative glomerulonephritis with monoclonal IgG deposits recurs or may develop de novo in kidney allografts.Template:21705124
19640387 PDF 2009. Characteristics of proliferative glomerulo-nephritis with monoclonal IgG deposits associated with membranoproliferative features.Template:19640387
16431264 PDF 2006. A proliferative glomerulonephritis secondary to a monoclonal IgA.Template:16431264
11423695 PDF 2001. Recurrence of light chain nephropathy in a renal allograft. A case report and review of the literature.Template:11423695
37803288 PDF 2023. Proliferative glomerulonephritis with monoclonal IgG Lambda deposits caused by plasmablastic lymphoma: a case report.Template:37803288
37548878 PDF 2023. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits and atypical pathological findings treated with corticosteroid and rituximab.Template:37548878
37393252 PDF 2023. Discordance of light chain isotypes between serum and glomerular deposits in proliferative glomerulonephritis with monoclonal IgG deposits: a case report and review of the literature.Template:37393252
37197047 PDF 2023. Proliferative Glomerulonephritis with Monoclonal Immunoglobulins in a Child with Recurrence in the Allograft.Template:37197047
37098508 PDF 2023. Proliferative glomerulonephritis with monoclonal IgG deposits: a unique case with a clinical course of over 46 years.Template:37098508
36913081 PDF 2023. IgA nephropathy to proliferative glomerulonephritis with monoclonal IgAkappa deposits: a pattern switch.Template:36913081

36714098 PDF 2022. Proliferative glomerulonephritis with monoclonal immunoglobulin G3 lambda deposits accompanied by glomerular positive staining for nephritis-associated plasmin receptor and related plasmin activity: A report of two cases.'

36654968 PDF 2023. Relapsing and Remitting Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Association With Infection and Vaccination: A Case Report.Template:36654968
36644361 PDF 2023. Overexpression of Plasmalemmal Vesicle-Associated Protein-1 Reflects Glomerular Endothelial Injury in Cases of Proliferative Glomerulonephritis with Monoclonal IgG Deposits.Template:36644361
36494791 PDF 2022. A rare case of proliferative glomerulonephritis with monoclonal IgG2 kappa deposit: a case report.Template:36494791
36312462 PDF 2022. An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature.Template:36312462
36217516 PDF 2022. Efficacy of Immunomodulatory Drugs in Combination With Dexamethasone in Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits.Template:36217516

36003672 PDF 2022. Glomerulonephritis with non-Randall-type, non-cryoglobulinaemic monoclonal immunoglobulin G deposits (PGNMID and ITG).'

35855226 PDF 2022. Proliferative Glomerulonephritis With Monotypic Immunoglobulin Deposits: An Unusual Presentation in the Setting of Multiple Inciting Events Including COVID-19 Vaccination.Template:35855226
35699924 PDF 2023. Diagnosis of monoclonal immunotactoid glomerulopathy with positive lambda chain by immunoelectron microscopy.Template:35699924
35522429 PDF 2022. Treatment with bortezomib for recurrent proliferative glomerulonephritis with monoclonal IgG deposits in kidney allograft. Case report and review of the literature.Template:35522429
35191627 PDF 2022. PGNMID and anti-CD38 monoclonal antibody: a therapeutic challenge.Template:35191627
35122206 PDF 2022. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits triggered by COVID-19: a case report.Template:35122206
35110486 PDF 2022. Proliferative Glomerulonephritis with Monoclonal IgG Deposits and Refractory Ascites: Successful Treatment with Rituximab and Cell-free and Concentrated Ascites Reinfusion Therapy.Template:35110486

35025059 PDF 2022. A case of proliferative glomerulonephritis with monoclonal IgG3kappa deposits accompanied by glomerular capillary microaneurysms.'

34628583 PDF 2022. A case of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) that responded favorably to steroid therapy.Template:34628583
34386672 PDF 2021. Two Cases of Proliferative Glomerulonephritis With Monoclonal IgG Deposits Treated With Renin Angiotensin Inhibition Alone With Long-term Follow-up.Template:34386672
34386669 PDF 2021. Daratumumab in Patients With Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits.Template:34386669
34158330 PDF 2021. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits associated with parvovirus B19.Template:34158330
33869614 PDF 2021. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits in a young woman: A case report.Template:33869614
33851621 PDF 2021. A tale of monoclonal immunoglobulin: Clinicopathological analysis of proliferative glomerulonephritis with monoclonal immunoglobulin deposit.Template:33851621
33685975 PDF 2021. Safety and Efficacy of Daratumumab in Patients with Proliferative GN with Monoclonal Immunoglobulin Deposits.Template:33685975
33489136 PDF 2021. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: Successful treatment for new and rare entity.Template:33489136
33398782 PDF 2021. Steroid-sensitive recurrent mesangial proliferative glomerulonephritis with monoclonal IgG deposits.Template:33398782
33392216 PDF 2020. Monoclonal Gammopathy of Renal Significance: Clinical and Histological Efficacy of a Bortezomib-Based Regimen.Template:33392216
33227797 PDF 2020. Recurrence of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits with a Striated Ultrastructure.Template:33227797

32734203 PDF 2019. Proliferative Glomerulonephritis With Monoclonal IgG3lambda Deposits: A Case Report of a Rare Cause of Monoclonal Gammopathy of Renal Significance.'

32518879 PDF 2020. KM55 Monoclonal Antibody and IgA Variant of Proliferative Glomerulonephritis With Monoclonal Ig Deposits.Template:32518879
32350770 PDF 2020. A case of proliferative glomerulonephritis with immunoglobulin A1-lambda deposits successfully treated by chemotherapy.Template:32350770
32221859 PDF 2020. Clone-directed therapy for proliferative glomerulonephritis with monoclonal immunoglobulin depositions: is it always necessary? : Two case reports and literature review.Template:32221859
31611527 PDF 2020. Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.Template:31611527

31331283 PDF 2019. Membranoproliferative glomerulonephritis with deposition of monoclonal IgG evolved from polyclonal IgG: a case report with two consecutive renal biopsies.'

30805792 PDF 2019. Chronological change of renal pathological findings in the proliferative glomerulonephritis with monoclonal IgG deposits considered to have recurred early after kidney transplantation.Template:30805792
30764798 PDF 2019. Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.Template:30764798
30567197 PDF 2018. Successful management of proliferative glomerulonephritis with monoclonal immune deposits with combined immunosuppressive therapy.Template:30567197

29987665 PDF 2018. Proliferative glomerulonephritis with unusual microlamellar organized deposits related to monoclonal immunoglobulin G3 (IgG3) kappa.'

29850460 PDF 2018. Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Lambda Deposits: Report of the First Pediatric Case.Template:29850460
29716794 PDF 2018. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft.Template:29716794
29706814 PDF 2018. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda chains.Template:29706814
29270532 PDF 2017. Proliferative Glomerulonephritis With Masked Monoclonal Deposits Responsive to Myeloma Therapy.Template:29270532
29230710 PDF 2018. A case report of proliferative glomerulonephritis with monoclonal immunoglobulin M-kappa deposits without associated lymphoproliferative disorder or detectable paraproteinemia.Template:29230710

29209544 PDF 2017. A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features.'

28975104 PDF 2017. Proliferative glomerulonephritis with monoclonal IgG deposits; an unusual cause of de novo disease in kidney allograft.Template:28975104
28616219 PDF 2017. Proliferative glomerulonephritis with monoclonal IgG deposits in two kidney allografts successfully treated with rituximab.Template:28616219
28385149 PDF 2017. Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report.Template:28385149
28381748 PDF 2017. Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation.Template:28381748
29142932 PDF 2016. Clinicopathologic Features of Membranous-Like Glomerulopathy With Masked IgG Kappa Deposits.Template:29142932
25484532 PDF 2014. Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature.Template:25484532
28509187 PDF 2014. Recurrent proliferative glomerulonephritis with monoclonal immunoglobulin G deposits leads to rapid graft loss after kidney transplantation: a case report.Template:28509187
25275829 PDF 2015. Recurrent Proliferative Glomerulonephritis With Monoclonal IgG Deposits After a Renal Transplant Which Was Insensitive to Pulse Therapy Remitted by Double Filtration Plasmapheresis.Template:25275829
25136462 PDF 2014. Nephrotic syndrome secondary to proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda light chain.Template:25136462

26069833 PDF 2013. Relapsing proliferative glomerulonephritis with monoclonal IgG deposits showing circumferential crescentic glomerulonephritis.'

28509294 PDF 2013. Proliferative glomerulonephritis with monoclonal IgM-kappa deposits in chronic lymphocytic leukemia/small lymphocytic leukemia: case report and review of the literature.Template:28509294
28509293 PDF 2013. Proliferative glomerulonephritis with monoclonal IgG2kappa deposit successfully treated with steroids: a case report and review of the literature.Template:28509293
23197955 PDF 2012. A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits after kidney transplant treated with plasmapheresis.Template:23197955
23169376 PDF 2012. Proliferative glomerulonephritis with monoclonal IgG deposits on multiple myeloma.Template:23169376

25949467 PDF 2010. Non-Randall proliferative glomerulonephritis with humps and monotypic IgG deposits in primary Sjogren's syndrome: a first case report.'

20876681 PDF 2011. Proliferative glomerulonephritis with monoclonal IgG deposits recurs in the allograft.Template:20876681
25949430 PDF 2010. Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features.Template:25949430
38192041 PDF 2024. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits in the native or posttransplant kidney.Template:38192041

37713183 PDF 2023. Characteristics of Complement Protein Deposition in Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition.'

37137693 PDF 2023. Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a clinicopathological study of three cases.Template:37137693
36652170 PDF 2023. Proliferative glomerulonephritis with monoclonal IgG deposits triggered by Filgrastim in a patient with multiple myeloma.Template:36652170

35931341 PDF 2023. Proliferative Glomerulonephritis With Hidden Monotypic IgG3kappa Deposits: A Case Report.'

35229819 PDF 2021. Cyclophosphamide for the Treatment of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition.Template:35229819
33774080 PDF 2021. Proliferative Glomerulonephritis With Fibrils, Monoclonal kappa Light Chain, and C3 Deposits.Template:33774080

33428097 PDF 2021. Pregnancy-associated proliferative glomerulonephritis with monoclonal immunoglobulin deposits.'

31313561 PDF 2018. Proliferative Glomerulonephritis with Monoclonal IgG Deposits.Template:31313561
30747850 PDF 2019. Recurrent Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allografts Treated With Anti-CD20 Antibodies.Template:30747850
30611830 PDF 2019. IgA-Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits.Template:30611830
29577510 PDF 2018. Successful treatment with steroid and cyclosporine A in a patient with immunoglobulin A-proliferative glomerulonephritis with monoclonal immunoglobulin deposits.Template:29577510
28628381 PDF 2017. Monoclonal immunoglobulin-associated proliferative glomerulonephritis characterized by organized deposits of striated ultra-substructures: A case report.Template:28628381
26997395 PDF 2016. Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft.Template:26997395
26976360 PDF 2016. De novo proliferative glomerulonephritis with monoclonal IgG deposits of the IgG1kappa subtype in a kidney allograft.Template:26976360
26971743 PDF 2016. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft.Template:26971743
26612277 PDF 2016. Proliferative Glomerulonephritis With Monoclonal IgG1kappa Deposits in a Hepatitis C Virus-Positive Patient.Template:26612277
25373138 PDF 2015. Recurrence of monoclonal IgA lambda glomerulonephritis in kidney allograft associated with multiple myeloma.Template:25373138
24842824 PDF 2014. Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft.Template:24842824
24051081 PDF 2014. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a kidney allograft.Template:24051081
23725649 PDF 2013. Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia.Template:23725649
23474011 PDF 2013. Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IgG2lambda subtype in a transplanted kidney: a case report.Template:23474011
23356227 PDF 2013. Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin gamma1 CH 2 heavy chain and kappa light chain: a new variant of monoclonal immunoglobulin deposition disease.Template:23356227
22819999 PDF 2012. Proliferative glomerulonephritis with monoclonal immunoglobulin G3kappa deposits in association with parvovirus B19 infection.Template:22819999

22377259 PDF 2012. Proliferative glomerulonephritis with monoclonal IgM deposits without Waldenstrom's macroglobulinemia: case report and review of the literature.'

21633102 PDF 2011. Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases.Template:21633102
20454825 PDF 2010. Renal involvement of monoclonal immunoglobulin deposition disease associated with an unusual monoclonal immunoglobulin A glycan profile.Template:20454825
34113625 PDF 2021. Membranous Nephropathy With Monoclonal IgM Lambda Deposits in a Patient With IgM Monoclonal Gammopathy: A Case Report.Template:34113625
33376611 PDF 2020. Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature.Template:33376611

33156494 PDF 2021. First case report of monoclonal IgG3-heavy-chain glomerulonephritis with microtubular structures.'

case of fibril forming IgG3 heavy chain deposition unique beyond classification.

EM organized deposits means fibril/microtubes: Amyloid, Immunotactoid, Fibrillary GN, Type I Cryoglobulin-GN

EM nonorganized means fine granular or powder-like: MIDD (LCDD, LHCDD, HCDD); PGNMID. {t{tp|p=23259458|t=2012. Membranoproliferative glomerulonephritis complicating Waldenstrom's macroglobulinemia.|pdf=|usr=}}Template:23259458

20185597 PDF 2010. Membranoproliferative glomerulonephritis secondary to monoclonal gammopathy.'

advice to the nephropathologist: all cases of Membranoproliferative GN to be assessed by Immunofluorescencs on paraffin-fixed, pronase-digested material to catch forms of MGRS.

26154922 PDF 2015. Membranoproliferative glomerulonephritis with masked monotypic immunoglobulin deposits.'