Cryo Crystalglobulins (MGRS)

35479195 PDF 2022. Crystalglobulin-Associated Kidney Disease: A Case Report and Literature Review.

• def. Crystaglobulins monoclonal Immunoglobulins, cryst. at normal temperature.
• def. Cryocrystagloulins same with Cryoglobulin property.
• def. Crystaglobulins assoc. nephropathy with crytallized fibrillary deposits; lobar accentuated glomeruli, mesangial cellularity, even intracellular material. IF at frozen biopsy subsensitive, pronase digest or immunoelectron microscopy needed. Clin. RPGN nephritic & nephrotic, cutaneous vasculitis and random systems involvement.
• Case shown w. clinical and histopathological images.

32734187 PDF 2019. Crystalglobulin-Induced Nephropathy and Keratopathy.

• sim. of crystalglobin-associated nephropathy: monoclonal protein–related crystalline nephropathies, light chain proximal tubulopathy, crystalline light chain cast nephropathy, crystal-storing histiocytosis, cryocrystalglobulinemia.

table of all Monoclonal Protein–Related Renal Lesions given.

• mech: crystallization in endoplasmic reticulum, lysosomes (re-uptake), the in capillary lumina as TMA-lookalikes or small-vessel vasculitis. lm: nospecific, subsensitive ihc, eosinophilic material, pronase-digest stains Ig.
• lab: myeloma workup, free light chains, marrow biopsy, albumin-autoantibodies, cryoglobulins.
• treat: independent of myeloma activity chemo, cases bone marrow transplant. heroic plasmapherisis.
• case: rpgn as tma-like lesion, corneal(eye) deposits (img shown)

25949411 PDF 2010. A case of bilateral renal arterial thrombosis associated with cryocrystalglobulinaemia.Template:25949411