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- Monoclonal immunoglobulin diseases include light-chain deposition disease, light- and heavy-chain deposition disease,heavy-chain deposition disease, type I cryoglobulinemia, immune tubular glomerulopathy and fibrillar glomerulopathy. In recent years, the spectrum of monoclonal gammopathy has gradually expanded to include tissue deposits of monoisotype Ig but lacks evidence for a circulating monoclonal Ig component.
- fibrillary glomerulopathy, cryoglobulinemia type 1, membranous glomerulonephritis with IgGκ deposition, light-chain amyloidosis, light- and heavy-chain deposition disease, lupus nephritis, atypical anti-GBM nephritis with IgG deposition and idiopathic MPGN.
- daratumumab ==anti cd38
- 0.8% of kidney biopsies
- 20% terminal ki; 90% graft recurrence w early graft loss.
- nephritic/nphrotic init.
- no cryoglobulins (dd: cryo-crystalglobulinemic disease)