Cryo Crystalglobulins (MGRS)

35479195 PDF 2022. Crystalglobulin-Associated Kidney Disease: A Case Report and Literature Review.

def. Crystaglobulins monoclonal Immunoglobulins, cryst. at normal temperature.
def. Cryocrystagloulins same with Cryoglobulin property.
def. Crystaglobulins assoc. nephropathy with crytallized fibrillary deposits; lobar accentuated glomeruli, mesangial cellularity, even intracellular material. IF at frozen biopsy subsensitive, pronase digest or immunoelectron microscopy needed. Clin. RPGN nephritic & nephrotic, cutaneous vasculitis and random systems involvement.
Case shown w. clinical and histopathological images.

32734187 PDF 2019. Crystalglobulin-Induced Nephropathy and Keratopathy.

sim. of crystalglobin-associated nephropathy: monoclonal protein–related crystalline nephropathies, light chain proximal tubulopathy, crystalline light chain cast nephropathy, crystal-storing histiocytosis, cryocrystalglobulinemia.

table of all Monoclonal Protein–Related Renal Lesions given.

mech: crystallization in endoplasmic reticulum, lysosomes (re-uptake), the in capillary lumina as TMA-lookalikes or small-vessel vasculitis. lm: nospecific, subsensitive ihc, eosinophilic material, pronase-digest stains Ig.
lab: myeloma workup, free light chains, marrow biopsy, albumin-autoantibodies, cryoglobulins.
treat: independent of myeloma activity chemo, cases bone marrow transplant. heroic plasmapherisis.
case: rpgn as tma-like lesion, corneal(eye) deposits (img shown)

25949411 PDF 2010. A case of bilateral renal arterial thrombosis associated with cryocrystalglobulinaemia.Template:25949411
4080955 PDF Widespread crystallisation of paraprotein in myelomatosis. Template:4080955
24660231 PDF Extracellular and intracellular crystal deposition in plasma cell myeloma. Template:24660231
21701535 PDF The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation. Template:21701535
25410550 PDF A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain. Template:25410550
25295579 PDF Light chain crystalline kidney disease: diagnostic urine microscopy as the "liquid kidney biopsy". Template:25295579
16354243 PDF Multiple myeloma-associated cast nephropathy with crystal structure: case report and review of the literature. Template:16354243
10846566 PDF Crystalglobulin-induced vasculopathy accompanying ischemic intestinal lesions of a patient with myeloma. Template:10846566
2108650 PDF Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma. Template:2108650
2558235 PDF [Specific cytoplasmic crystalline inclusions in multiple myeloma with amyloidosis]. Template:2558235
2492415 PDF A vasculopathy with deposition of lambda light chain crystals. Template:2492415

First description Bohnsdorff, Groth, Pakalen 1938, Über Hyperproteinämie und damit zusammenhängende Phänomene beim Myelom.