Structure Signal Transduction

related: Lipid regulation of ion channels

30305398 PDF 2018. Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg(2+), spermine, and pH.Template:30305398
30108148 PDF 2018. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.Template:30108148
29866880 PDF 2018. The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells.Template:29866880
37449820 PDF 2023. Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15.Template:37449820
37156763 PDF 2023. Structural mechanisms of TRPM7 activation and inhibition.Template:37156763
37040321 PDF 2023. Effect of truncation on TRPM7 channel activity.Template:37040321
36982474 PDF 2023. TRPM7-Mediated Ca(2+) Regulates Mussel Settlement through the CaMKKbeta-AMPK-SGF1 Pathway.Template:36982474
36972446 PDF 2023. PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics.Template:36972446
36711628 PDF 2023. Structural insights into regulation of TRPM7 divalent cation uptake by the small GTPase ARL15.Template:36711628
36027648 PDF 2022. Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7.Template:36027648
35841930 PDF 2022. Recent Advances in the Structural Biology of Mg(2+) Channels and Transporters.Template:35841930
35819535 PDF 2022. Structural and functional comparison of magnesium transporters throughout evolution.Template:35819535
35389104 PDF 2022. Structural mechanism of TRPM7 channel regulation by intracellular magnesium.Template:35389104
35002778 PDF 2021. Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010's.Template:35002778
34928937 PDF 2021. CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells.Template:34928937
34917797 PDF 2021. TRPM7 N-terminal region forms complexes with calcium binding proteins CaM and S100A1.Template:34917797
34766907 PDF 2021. The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics.Template:34766907
34627839 PDF 2021. The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation.Template:34627839
34504177 PDF 2021. Distinct calcium regulation of TRPM7 mechanosensitive channels at plasma membrane microdomains visualized by FRET-based single cell imaging.Template:34504177
34017036 PDF 2021. TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel.Template:34017036
33999118 PDF 2021. The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity.Template:33999118
38019640 PDF 2023. DNA Sensor-Based Strategy to Visualize the TRPM7 mRNA-Mg(2+) Signaling Pathway in Cancer Cells.Template:38019640
37222397 PDF 2023. New insights into the structure and function of CNNM proteins.Template:37222397
30470536 PDF 2018. TRPM7 reflected in Cryo-EMirror.Template:30470536
30406297 PDF 2019. Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg(2+) Transporters Other than TRPM6/7.Template:30406297
31812825 PDF 2020. A structural overview of the ion channels of the TRPM family.Template:31812825
31392516 PDF 2020. Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function.Template:31392516
31355337 PDF 2019. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area.Template:31355337
31140077 PDF 2019. Investigating Phosphorylation Patterns of the Ion Channel TRPM7 Using Multiple Extraction and Enrichment Techniques Reveals New Phosphosites.Template:31140077
30995736 PDF 2019. TRPM7, Magnesium, and Signaling.Template:30995736
29500477 PDF 2018. The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins.Template:29500477
28821869 PDF 2017. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg.ATP.Template:28821869
26179995 PDF 2015. The Different Roles of The Channel-Kinases TRPM6 and TRPM7.Template:26179995
24961969 PDF 2014. TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters).Template:24961969
28220887 PDF 2017. Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.Template:28220887

28130783 PDF 2017. The TRPM7 channel kinase regulates store-operated calcium entry.'

28129376 PDF 2017. Modulation of Human Cardiac TRPM7 Current by Extracellular Acidic pH Depends upon Extracellular Concentrations of Divalent Cations.Template:28129376
27651019 PDF 2016. The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?Template:27651019
27628598 PDF 2016. The coiled-coil domain of zebrafish TRPM7 regulates Mg.nucleotide sensitivity.Template:27628598
26658739 PDF 2015. Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase C.Template:26658739
26504086 PDF 2015. Trpm7 Protein Contributes to Intercellular Junction Formation in Mouse Urothelium.Template:26504086
15069188 PDF 2004. Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.Template:15069188
14594813 PDF 2004. Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel.Template:14594813
12887921 PDF 2003. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7.Template:12887921
24291108 PDF 2014. How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.Template:24291108
22222377 PDF 2012. Identification of the phosphorylation sites on intact TRPM7 channels from mammalian cells.Template:22222377
21290315 PDF 2011. TRP channels as mediators of oxidative stress.Template:21290315
21290305 PDF 2011. Investigations of the in vivo requirements of transient receptor potential ion channels using frog and zebrafish model systems.Template:21290305
21290295 PDF 2011. TRPM7, the Mg(2+) inhibited channel and kinase.Template:21290295
20861666 PDF 2010. TRPM7 and magnesium, metabolism, mitosis: An old path with new pebbles.Template:20861666
20237584 PDF 2010. Flickering calcium microdomains signal turning of migrating cells.Template:20237584
19842065 PDF 2010. Mechanotransduction by TRP channels: general concepts and specific role in the vasculature.Template:19842065
19803432 PDF 2009. [TRPM7: a membrane protein with ion channel and kinase activities].Template:19803432
19228120 PDF 2009. Identification of dimer interactions required for the catalytic activity of the TRPM7 alpha-kinase domain.Template:19228120
18719395 PDF 2008. Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+.Template:18719395
26149285 PDF 2016. Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation.Template:26149285
25946314 PDF 2015. Rapid and Localized Mechanical Stimulation and Adhesion Assay: TRPM7 Involvement in Calcium Signaling and Cell Adhesion.Template:25946314
25534891 PDF 2014. Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice.Template:25534891
25418090 PDF 2014. Physiological pathway of magnesium influx in rat ventricular myocytes.Template:25418090
25326319 PDF 2014. Identification of a Mg2+-sensitive ORF in the 5'-leader of TRPM7 magnesium channel mRNA.Template:25326319
25079291 PDF 2014. Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer.Template:25079291
25030553 PDF 2014. Inactivation of TRPM7 kinase activity does not impair its channel function in mice.Template:25030553

24858416 PDF 2014. TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.'

24855944 PDF 2014. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.'

24752033 PDF 2014. The channel-kinase TRPM7, revealing the untold story of Mg(2+) in cellular signaling.Template:24752033
24747489 PDF 2014. Mg(2+)- and ATP-dependent inhibition of transient receptor potential melastatin 7 by oxidative stress.Template:24747489
24650431 PDF 2014. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.Template:24650431
24634592 PDF 2014. The Pathophysiologic Roles of TRPM7 Channel.Template:24634592
24385424 PDF 2014. The TRPM6 kinase domain determines the Mg.ATP sensitivity of TRPM7/M6 heteromeric ion channels.Template:24385424
24161127 PDF 2014. Redox regulation of transient receptor potential channels.Template:24161127
23471296 PDF 2013. TRPM7 is regulated by halides through its kinase domain.Template:23471296
23186176 PDF 2013. Sphingosine and the transient receptor potential channel kinase(s).Template:23186176

16357306 PDF 2006. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow.'

16001276 PDF 2005. TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors.Template:16001276
15902429 PDF 2005. Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes.Template:15902429
14764909 PDF 2004. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms.Template:14764909
11941371 PDF 2002. The TRPM7 channel is inactivated by PIP(2) hydrolysis.Template:11941371
11509717 PDF 2001. Biochemistry. TRP ion channels--two proteins in one.Template:11509717

11385574 PDF 2001. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.'

11385555 PDF 2001. Cell biology. Channels as enzymes.Template:11385555
22934072 PDF 2012. TRP channels: sensors and transducers of gasotransmitter signals.Template:22934072
22698280 PDF 2012. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.Template:22698280
22587440 PDF 2012. A key role for Mg(2+) in TRPM7's control of ROS levels during cell stress.Template:22587440
22301056 PDF 2012. Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels.Template:22301056
22180838 PDF 2011. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity.Template:22180838
22102510 PDF 2012. Modulation of transient receptor potential melastatin related 7 channel by presenilins.Template:22102510
21627970 PDF 2011. The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7.Template:21627970
21566016 PDF 2011. Basally activated nonselective cation currents regulate the resting membrane potential in human and monkey colonic smooth muscle.Template:21566016
21487014 PDF 2011. Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro.Template:21487014
21471721 PDF 2011. Alteration of the transcriptional profile of human embryonic kidney cells by transient overexpression of mouse TRPM7 channels.Template:21471721
21280599 PDF 2011. Phosphorylation of annexin A1 by TRPM7 kinase: a switch regulating the induction of an alpha-helix.Template:21280599
21208190 PDF 2011. TRPM7 regulates polarized cell movements.Template:21208190
21112387 PDF 2011. The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.Template:21112387
20932259 PDF 2011. TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions.Template:20932259
20075334 PDF 2010. TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation.Template:20075334
20070945 PDF 2010. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase.Template:20070945
20012461 PDF 2010. The alpha-kinase family: an exceptional branch on the protein kinase tree.Template:20012461
19780399 PDF 2009. Epithelial Mg2+ channel TRPM6: insight into the molecular regulation.Template:19780399
19118385 PDF 2009. Calcium flickers steer cell migration.Template:19118385
18782578 PDF 2008. X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil.Template:18782578
18675813 PDF 2008. The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.Template:18675813
18590694 PDF 2008. TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.Template:18590694
18394644 PDF 2008. TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.Template:18394644

18390554 PDF 2008. Proton conductivity through the human TRPM7 channel and its molecular determinants.'

18365021 PDF 2008. Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.Template:18365021

17913893 PDF 2007. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations.'

17646711 PDF 2007. Regulation of transient receptor potential melastatin 7 (TRPM7) currents by mitochondria.'

17599911 PDF 2007. Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.Template:17599911
17510191 PDF 2007. TRPM7 channel is sensitive to osmotic gradients in human kidney cells.Template:17510191

17310095 PDF 2007. Direct mechano-stress sensitivity of TRPM7 channel.'

11161216 PDF 2001. TRP-PLIK, a bifunctional protein with kinase and ion channel activities.'

36993210 PDF 2023. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.Template:36993210
35406753 PDF 2022. On the Connections between TRPM Channels and SOCE.Template:35406753
20399884 PDF 2010. Cellular functions of transient receptor potential channels.Template:20399884

17233613 PDF 2007. Regulation of TRP channels: a voltage-lipid connection.'

17217066 PDF 2007. The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7.Template:17217066
17098283 PDF 2007. Molecular determinants of permeation through the cation channel TRPM6.Template:17098283
17064762 PDF 2007. Cell cycle-dependent regulation of store-operated I(CRAC) and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents.Template:17064762

16943238 PDF 2007. TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.'

16636202 PDF 2006. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.Template:16636202
16533898 PDF 2006. TRPM7 channel is regulated by magnesium nucleotides via its kinase domain.Template:16533898
16436382 PDF 2006. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.Template:16436382
16407977 PDF 2006. TRPM7, a novel regulator of actomyosin contractility and cell adhesion.Template:16407977

16260839 PDF 2005. Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels.'

16150690 PDF 2005. The channel kinases TRPM6 and TRPM7 are functionally nonredundant.Template:16150690
16009728 PDF 2005. Potentiation of TRPM7 inward currents by protons.Template:16009728
15781465 PDF 2005. Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1.Template:15781465
15485879 PDF 2004. Phosphorylation of annexin I by TRPM7 channel-kinase.Template:15485879
24890046 PDF 2014. Gene regulation: Chanzyme in action--divide and conquer?Template:24890046
33035451 PDF 2020. Lactate Elicits ER-Mitochondrial Mg(2+) Dynamics to Integrate Cellular Metabolism.Template:33035451
31149807 PDF 2019. Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels.Template:31149807
25633344 PDF 2015. Lipid agonism: The PIP2 paradigm of ligand-gated ion channels.Template:25633344
23916247 PDF 2013. Regulation of transient receptor potential channels by the phospholipase C pathway.Template:23916247
21640700 PDF 2011. Cellular magnesium homeostasis.Template:21640700
21290288 PDF 2011. Functional and structural studies of TRP channels heterologously expressed in budding yeast.Template:21290288
21290287 PDF 2011. Structural biology of TRP channels.Template:21290287
21126186 PDF 2011. Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels.Template:21126186
19923421 PDF 2010. Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.Template:19923421
18573078 PDF 2008. PIP2 is a necessary cofactor for ion channel function: how and why?Template:18573078
37620401 PDF 2023. Intracellular Mg(2+) protects mitochondria from oxidative stress in human keratinocytes.Template:37620401
31184289 PDF 2019. TRP ion channels: Proteins with conformational flexibility.Template:31184289
30910771 PDF 2019. Transient Receptor Potential Channels and Calcium Signaling.Template:30910771
24717323 PDF 2014. Post-Translational Modifications of TRP Channels.Template:24717323
23720286 PDF 2013. Molecular mechanism of TRP channels.Template:23720286
23151432 PDF 2012. Keeping active channels in their place: membrane phosphoinositides regulate TRPM channel activity in a compartment-selective manner.Template:23151432
20861159 PDF 2010. The role of transient receptor potential cation channels in Ca2+ signaling.Template:20861159
19376575 PDF 2009. Phosphoinositide regulation of non-canonical transient receptor potential channels.Template:19376575
16806461 PDF 2006. TRP channels and Ca2+ signaling.Template:16806461
37894842 PDF 2023. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.Template:37894842
31972006 PDF 2020. Structural mechanisms of transient receptor potential ion channels.Template:31972006
29706896 PDF 2018. Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions.Template:29706896
24961984 PDF 2014. Phosphoinositide regulation of TRP channels.Template:24961984
24961976 PDF 2014. Structural biology of TRP channels.Template:24961976
22016736 PDF 2011. TRP Channels as Sensors and Signal Integrators of Redox Status Changes.Template:22016736
21401968 PDF 2011. The transient receptor potential family of ion channels.Template:21401968
21296744 PDF 2011. Transient receptor potential (TRP) gene superfamily encoding cation channels.Template:21296744
20399884 PDF 2010. Cellular functions of transient receptor potential channels.Template:20399884
19237588 PDF 2009. Hot on the trail of TRP channel structure.Template:19237588
19237587 PDF 2009. Divide and conquer: high resolution structural information on TRP channel fragments.Template:19237587
19237586 PDF 2009. Perspectives on TRP channel structure and the TRPA1 puzzle.Template:19237586
17217066 PDF 2007. The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7.Template:17217066
34188059 PDF 2021. Crystal structure of an archaeal CorB magnesium transporter.Template:34188059
33676926 PDF 2021. Structural Pharmacology of TRP Channels.Template:33676926
32159767 PDF 2020. Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS).Template:32159767
30374082 PDF 2018. Organellar TRP channels.Template:30374082
24532247 PDF 2014. Physiological and pathological functions of mechanosensitive ion channels.Template:24532247
20132470 PDF 2010. TRP channels of intracellular membranes.Template:20132470
18535090 PDF 2008. TRP channels entering the structural era.Template:18535090
18394644 PDF 2008. TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.Template:18394644
17395625 PDF 2007. Modulation of TRPs by PIPs.Template:17395625
17138610 PDF 2007. TRPpathies.Template:17138610
16990401 PDF 2007. TRP channels and lipids: from Drosophila to mammalian physiology.Template:16990401
37502932 PDF 2023. Mitochondrial Magnesium is the cationic rheostat for MCU-mediated mitochondrial Ca(2+) uptake.Template:37502932
32842926 PDF 2020. Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature.Template:32842926
29464560 PDF 2018. Transient Receptor Potential (TRP) Channels.Template:29464560
28346371 PDF 2017. Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential.Template:28346371
25407951 PDF 2014. Distinct modes of perimembrane TRP channel turnover revealed by TIR-FRAP.Template:25407951
25106481 PDF 2015. Permeation, regulation and control of expression of TRP channels by trace metal ions.Template:25106481
24339795 PDF 2013. Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.Template:24339795
21203922 PDF 2010. Heteromerization of TRP channel subunits: extending functional diversity.Template:21203922
18927203 PDF 2008. The unique nature of mg2+ channels.Template:18927203
36754568 PDF 2023. The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity.Template:36754568
35686986 PDF 2022. Sequence and structural conservation reveal fingerprint residues in TRP channels.Template:35686986
30755796 PDF 2019. Recent advances in our understanding of the structure and function of more unusual cation channels.Template:30755796
29589513 PDF 2018. X-ray crystallography of TRP channels.Template:29589513
27809396 PDF 2017. Redox regulation of transient receptor potential channels in the endothelium.Template:27809396
24894720 PDF 2014. Application of amphipols for structure-functional analysis of TRP channels.Template:24894720
21112948 PDF 2011. Sphingolipids regulate [Mg2+]o uptake and [Mg2+]i content in vascular smooth muscle cells: potential mechanisms and importance to membrane transport of Mg2+.Template:21112948
C2884646 PDF 2009. Transient receptor potential (TRP) cation channels.Template:C2884646
24938632 PDF 2014. Epigenetics: the TRPM7 ion channel modifies histones.Template:24938632
30615643 PDF 2019. TRPM7 residue S1269 mediates cAMP dependence of Ca2+ influx.Template:30615643
36920646 PDF 2023. TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.Template:36920646
22759789 PDF 2012. Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C gamma2 (PLCgamma2) using TRPM7-kinase.Template:22759789
18769037 PDF 2008. Inhibition of the magnesium-sensitive TRPM7-like channel in cardiac myocytes by nonhydrolysable GTP analogs: involvement of phosphoinositide metabolism.Template:18769037
16707555 PDF 2006. ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes.Template:16707555
15050379 PDF 2004. Alpha-kinases: analysis of the family and comparison with conventional protein kinases.Template:15050379
24890046 PDF 2014. Gene regulation: Chanzyme in action--divide and conquer?Template:24890046
29690581 PDF 2018. Ca(2+) Regulation of TRP Ion Channels.Template:29690581
12601087 PDF 2003. Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6.Template:12601087
31726322 PDF 2019. Structural biology of thermoTRPV channels.Template:31726322
37736816 PDF 2023. Intrinsically disordered regions in TRPV2 mediate protein-protein interactions.Template:37736816
35652046 PDF 2022. Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.Template:35652046
32004513 PDF 2020. TRPC channels: Structure, function, regulation and recent advances in small molecular probes.Template:32004513