TRPM7
TRPM7 as member or the Transient Receptor Potential Ion Channel family is a nonselective cation channel which is inhibited by magnesium. It imports toxic cations like Zn2+, Cd2+, Co2+, and its kinase function hase some specific effects. Activity is needed for cellular magnesium import. Essential for Fibrosis (EMT), Calcification processes, Cell viability, it transforms magnesium action into cardiovascular, renal and neurologic diseases. While clinical trial data on magnesium substitution is lacking, physiological effects of established leads as sacubitril, candesartan, and aldosterone antagonism act as TRPM7 inhibitors.
Actual PubMed searches run with [www.moremed.org/sitesearch.php] will be sorted into these topical collections:
- Bone and Implants (TRPM7)
- Vascular Calcification (TRPM7)
- Hypertension
- Glomus caroticus
- Diabetes (TRPM7)
- Nephrology clinical (TRPM7)
- Fibrosis (TRPM7)