Editing TRPM8

as i had the scabies i felt innerly cold as ice. not based.

{{tp|p=18684990|t=2008. Cooling skin cancer: menthol inhibits melanoma growth. Focus on "TRPM8 activation suppresses cellular viability in human melanoma".|pdf=|usr=}}{{18684990}}
{{tp|p=37857704|t=2023. Structure of human TRPM8 channel.|pdf=|usr=}}{{37857704}}
{{tp|p=35662242|t=2022. Structures of a mammalian TRPM8 in closed state.|pdf=|usr=}}{{35662242}}
{{tp|p=31488702|t=2019. Structural insights into TRPM8 inhibition and desensitization.|pdf=|usr=}}{{31488702}}
{{tp|p=29217583|t=2018. Structure of the cold- and menthol-sensing ion channel TRPM8.|pdf=|usr=}}{{29217583}}
{{tp|p=37373205|t=2023. Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes-TRPA1 and TRPM8 as Potential Drug Targets.|pdf=|usr=}}{{37373205}}
{{tp|p=33655414|t=2021. Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8.|pdf=|usr=}}{{33655414}}
{{tp|p=28053885|t=2017. Shakuyakukanzoto attenuates oxaliplatin-induced cold dysesthesia by inhibiting the expression of transient receptor potential melastatin 8 in mice.|pdf=|usr=}}{{28053885}}
{{tp|p=27131832|t=2016. Topical menthol increases cutaneous blood flow.|pdf=|usr=}}{{27131832}}
{{tp|p=23441811|t=2013. Cold stress induces lower urinary tract symptoms.|pdf=|usr=}}{{23441811}}
{{tp|p=26657057|t=2016. Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance.|pdf=|usr=}}{{26657057}}
{{tp|p=24372189|t=2014. TRP channels in the skin.|pdf=|usr=}}{{24372189}}
{{tp|p=34734022|t=2021. Cold-inducible RNA-binding protein migrates from the nucleus to the cytoplasm under cold stress in normal human bronchial epithelial cells via TRPM8-mediated mechanism.|pdf=|usr=}}{{34734022}}
{{tp|p=34589786|t=2021. Role of TRPM8 in switching between fever and hypothermia in adult mice during endotoxin-induced inflammation.|pdf=|usr=}}{{34589786}}
{{tp|p=32400133|t=2020. Activation of Transient Receptor Potential Melastatin Family Member 8 (TRPM8) Receptors Induces Proinflammatory Cytokine Expressions in Bronchial Epithelial Cells.|pdf=|usr=}}{{32400133}}
{{tp|p=31216483|t=2019. Direct Galpha(q) Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation.|pdf=|usr=}}{{31216483}}
{{tp|p=29972224|t=2018. Modulation of Itch by Localized Skin Warming and Cooling.|pdf=|usr=}}{{29972224}}
{{tp|p=26536261|t=2015. Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel.|pdf=|usr=}}{{26536261}}
{{tp|p=26341484|t=2015. Redox and trace metal regulation of ion channels in the pain pathway.|pdf=|usr=}}{{26341484}}
{{tp|p=25894692|t=2015. Molecular and cellular mechanisms that initiate pain and itch.|pdf=|usr=}}{{25894692}}
{{tp|p=23850286|t=2013. Polyester modification of the mammalian TRPM8 channel protein: implications for structure and function.|pdf=|usr=}}{{23850286}}
{{tp|p=23651844|t=2013. Enhanced insulin clearance in mice lacking TRPM8 channels.|pdf=|usr=}}{{23651844}}
{{tp|p=22860192|t=2012. Modulation of thermoreceptor TRPM8 by cooling compounds.|pdf=|usr=}}{{22860192}}
{{tp|p=19203589|t=2009. Roles of transient receptor potential channels in pain.|pdf=|usr=}}{{19203589}}
{{tp|p=37781093|t=2023. Peripheral mechanisms of peripheral neuropathic pain.|pdf=|usr=}}{{37781093}}
{{tp|p=36439160|t=2022. Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation.|pdf=|usr=}}{{36439160}}
{{tp|p=35847920|t=2022. Comprehensive Pan-Cancer Analysis of TRPM8 in Tumor Metabolism and Immune Escape.|pdf=|usr=}}{{35847920}}
{{tp|p=31293565|t=2019. Pruritus in Autoimmune and Inflammatory Dermatoses.|pdf=|usr=}}{{31293565}}
{{tp|p=26242276|t=2015. Pilot study to determine whether transient receptor potential melastatin type 8 (TRPM8) antibodies are detected in scleroderma.|pdf=|usr=}}{{26242276}}
{{tp|p=21903934|t=2011. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants.|pdf=|usr=}}{{21903934}}
{{tp|p=36675074|t=2023. Pathogenesis and Treatment of Pruritus Associated with Chronic Kidney Disease and Cholestasis.|pdf=|usr=}}{{36675074}}
{{tp|p=36536695|t=2022. Global Trends and Hotspots of Transient Receptor Potential Melastatin 8 Research from 2002 to 2021: A Bibliometric Analysis.|pdf=|usr=}}{{36536695}}
{{tp|p=35897101|t=2022. Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol.|pdf=|usr=}}{{35897101}}
{{tp|p=34446569|t=2021. Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function.|pdf=|usr=}}{{34446569}}
{{tp|p=31114308|t=2019. Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-kappaB signaling in the dorsal root ganglion of rats with neuropathic pain.|pdf=|usr=}}{{31114308}}
{{tp|p=30545944|t=2019. The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels.|pdf=|usr=}}{{30545944}}
{{tp|p=29880642|t=2018. Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison.|pdf=|usr=}}{{29880642}}
{{tp|p=29530988|t=2018. Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice.|pdf=|usr=}}{{29530988}}
{{tp|p=27845197|t=2017. Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia.|pdf=|usr=}}{{27845197}}
{{tp|p=27634619|t=2016. TRPM8 and Migraine.|pdf=|usr=}}{{27634619}}
{{tp|p=25157108|t=2014. The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.|pdf=|usr=}}{{25157108}}
{{tp|p=24917670|t=2014. Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain.|pdf=|usr=}}{{24917670}}
{{tp|p=23884957|t=2013. Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.|pdf=|usr=}}{{23884957}}
{{tp|p=22323721|t=2012. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.|pdf=|usr=}}{{22323721}}
{{tp|p=21900509|t=2011. TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis.|pdf=|usr=}}{{21900509}}
{{tp|p=21282398|t=2011. Voltage- and cold-dependent gating of single TRPM8 ion channels.|pdf=|usr=}}{{21282398}}
{{tp|p=18077679|t=2007. TRPM8 mechanism of cold allodynia after chronic nerve injury.|pdf=|usr=}}{{18077679}}
{{tp|p=36966947|t=2023. Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.|pdf=|usr=}}{{36966947}}
{{tp|p=36295712|t=2022. Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.|pdf=|usr=}}{{36295712}}
{{tp|p=35997391|t=2022. Pathophysiology of Nociception and Rare Genetic Disorders with Increased Pain Threshold or Pain Insensitivity.|pdf=|usr=}}{{35997391}}
{{tp|p=34834317|t=2021. The Use of Menthol in Skin Wound Healing-Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization.|pdf=|usr=}}{{34834317}}
{{tp|p=34717968|t=2022. Menthol-induced activation of TRPM8 receptors increases cutaneous blood flow across the dermatome.|pdf=|usr=}}{{34717968}}
{{tp|p=32955611|t=2021. TRPV4 and TRPM8 as putative targets for chronic low back pain alleviation.|pdf=|usr=}}{{32955611}}
{{tp|p=32728032|t=2020. Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel.|pdf=|usr=}}{{32728032}}
{{tp|p=32290846|t=2020. Chronic morphine regulates TRPM8 channels via MOR-PKCbeta signaling.|pdf=|usr=}}{{32290846}}
{{tp|p=31869278|t=2020. Physiology and Pathophysiology of Itch.|pdf=|usr=}}{{31869278}}
{{tp|p=29541177|t=2018. RNA interference-mediated depletion of TRPM8 enhances the efficacy of epirubicin chemotherapy in prostate cancer LNCaP and PC3 cells.|pdf=|usr=}}{{29541177}}
{{tp|p=29164310|t=2018. Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature.|pdf=|usr=}}{{29164310}}
{{ttp|p=29088850|t=2017. Dietary menthol-induced TRPM8 activation enhances WAT "browning" and ameliorates diet-induced obesity.|pdf=|usr=}}{{29088850}}
{{tp|p=28358322|t=2017. Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine.|pdf=|usr=}}{{28358322}}
{{tp|p=28039451|t=2017. High-throughput proteome analysis reveals targeted TRPM8 degradation in prostate cancer.|pdf=|usr=}}{{28039451}}
{{tp|p=28038937|t=2017. Cellular permeation of large molecules mediated by TRPM8 channels.|pdf=|usr=}}{{28038937}}
{{tp|p=27131832|t=2016. Topical menthol increases cutaneous blood flow.|pdf=|usr=}}{{27131832}}
{{tp|p=26870186|t=2016. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.|pdf=|usr=}}{{26870186}}
{{tp|p=25433072|t=2015. Molecular mechanisms of temperature adaptation.|pdf=|usr=}}{{25433072}}
{{tp|p=22571355|t=2012. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation.|pdf=|usr=}}{{22571355}}
{{tp|p=22292988|t=2012. L type Ca(2)+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats.|pdf=|usr=}}{{22292988}}
{{tp|p=22061619|t=2012. Regulation of TRPM8 channel activity.|pdf=|usr=}}{{22061619}}
{{tp|p=18534015|t=2008. TRPM8 mechanism of autonomic nerve response to cold in respiratory airway.|pdf=|usr=}}{{18534015}}
{{tp|p=17317754|t=2007. Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.|pdf=|usr=}}{{17317754}}
{{tp|p=36227998|t=2022. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP(2).|pdf=|usr=}}{{36227998}}
{{tp|p=32843690|t=2020. Highly functionalized beta-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity.|pdf=|usr=}}{{32843690}}
{{tp|p=32220960|t=2020. A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8.|pdf=|usr=}}{{32220960}}
{{tp|p=31575973|t=2019. Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP(2) Suggest a Mechanism for Regulation.|pdf=|usr=}}{{31575973}}
{{tp|p=27227023|t=2015. Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8.|pdf=|usr=}}{{27227023}}
{{tp|p=21767774|t=2011. Topical therapies for pruritus.|pdf=|usr=}}{{21767774}}
{{tp|p=17183631|t=2006. Neural substrate of cold-seeking behavior in endotoxin shock.|pdf=|usr=}}{{17183631}}
{{tp|p=37033630|t=2023. Therapeutic potential of TRPM8 channels in cancer treatment.|pdf=|usr=}}{{37033630}}
{{tp|p=33344232|t=2020. Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy.|pdf=|usr=}}{{33344232}}
{{tp|p=37834183|t=2023. Pathomechanism of Pruritus in Psoriasis and Atopic Dermatitis: Novel Approaches, Similarities and Differences.|pdf=|usr=}}{{37834183}}
{{tp|p=34445208|t=2021. TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.|pdf=|usr=}}{{34445208}}
{{tp|p=34861341|t=2022. Role of TRP ion channels in pruritus.|pdf=|usr=}}{{34861341}}
{{tp|p=29282613|t=2018. Regulation of Pain and Itch by TRP Channels.|pdf=|usr=}}{{29282613}}
{{tp|p=15847696|t=2005. How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation.|pdf=|usr=}}{{15847696}}
{{tp|p=30858386|t=2019. ADP-Ribose and oxidative stress activate TRPM8 channel in prostate cancer and kidney cells.|pdf=|usr=}}{{30858386}}
{{tp|p=27983625|t=2016. TRP Channels in Skin Biology and Pathophysiology.|pdf=|usr=}}{{27983625}}